IGM Publication
Email : Info@igmpublication.org Online ISSN : 2347-176X
Journal of Medical Science And Clinical Research
An Oficial Publication Of IGM publication
IGM Publication
Email : Info@igmpublication.org Online ISSN : 2347-176X
JMSCR Contents
Authors : M.Pramila Padmini, J. Vijay Kumar
Drug-induced nephrotoxicity is an important cause of renal failure. Aminoglycosides throughout the endocytic pathway are taken up into the epithelial cells of the renal proximal tubules and stay there for a long time, which leads to nephrotoxicity. Wistar‐albino male rats weighing 125–150gms, are utilized for the present study.Blood samples were collected with cardiac puncture for biochemical investigations like blood urea, uric acid, creatinine, serum Na, K, Ca, determination.By using one way ANOVA the results are significant at .001. Hyaline cast formation is observed in PCT with atrophic glomeruli effecting half of the cortical region when rats treated with 80mg/kg b.w. administration of Punarnava 400mg and 800mg/kg.bw rejuvenated necrotic cells of kidney .Gentamicin must be given in the lowest effective therapeutic doses in patients with normal kidney function along with punarnava.
Authors : Gaurav Kumar Singh, Beena Derajira Bopanna and Ganesh Rindhe
Staphylococcus aureus is one of the most significant pathogens causing nosocomial and skin infection. It is an opportunistic bacterium, frequently part of the human micro flora, causing disease when the immune system becomes compromised. Many genotypic variants and antibiotic strains have also been reported in the earlier studies. Therefore, the present study was carried out to examine the genotypic variations of S. aureus in different clinical samples. Six different samples of S. aureus isolated from Urinary tract infection (UTI), knee wound and sputum were subjected for various biochemical tests to confirm the identity of S. aureus as a pathogen. Molecular characterization of these isolates was carried out by using random amplified polymorphic DNA (RAPD). Out of five primers (D-18, D-20, T-7, W-2 and X-6) tested D-20 produced maximum number of bands. From the result obtained, it was seen that clinical isolates of S. aureus from knee wound (SA-1) and sputum sample (SA-6) are closely related. Close relation was also observed between sputum sample (SA-4) and UTI sample (SA-5). In conclusion, S. aureus strains are not specific for infection.
Title : Children Active Learning through Unstructured Play
Authors : Ismail Abdul Fatai O and Asrul Faqih,Wafa K Bustan
The Disposition of most adults to children playing is not encouraging due to the preconceived notion that children who play are often likely to be un-intelligent and hardly succeed in their academic pursuit. As a result, most parents hinder their children from playing, believing that it is an unprofitable venture. This popular notion on children’s playing triggers this study, to the extent that most parents as well as educational institutions for young children do not provide a conducive environment for them to play. This study is qualitatively designed; observation was used for data collection where the researchers watched some children aged 3 to 5 playing in their natural setting. In-depth analysis with the observation reveals that unstructured play could make young children learn through cooperation, gain knowledge and experience through imitation as well as gaining insight to new knowledge through trial and error. If the majority of parents, teachers and educators are aware of this, they could provide a comfortable environment for children to play in order to develop them physically, mentally and psychologically.
Author: Pandian Sankara Kumaran, Tamilvanan M
primary onset of this study is to determine the short and longer term effects of dual task training gait on walking performance when dual tasking in people with Parkinson’s disease.. The aim of the study is to analyze the efficacy of dual task training to improve functional gait performance in idiopathic Parkinson’s disease subjects
Title : Study on Variation of Exon 8 and 16 of Goat MLPH Gene
Authors : Liying ZHANG, Qiang FU, Xianglong LI , Lanhui LI and Rongyan ZHOU
The variation of exon 8 and 16 of MLPH gene in different Chinese indigenous goat breeds with different color and locations was investigated in order to understand its genetic diversity. The mutation sites g.G9109A and g.G9125A in exon 8 and g.G18951A and g.A18955C in exon 16 were found. The g.G18951A and g.A18955C in exon 16 were in complete linkage disequilibrium and formed two haplotypes, GA and AC. Meanwhile the complete linkage mutation sites in exon 16 were in second structure domain of MLPH protain, which might affect its function. Leizhou black goat, Jining grey goat and Liaoning Cashmere goat were in Hardy-Wenberg disequilibrium at g.G18951A and g.A18955C in exon 16 except for Nanjiang Brown goat. In exon 16, Jining grey goat and Liaoning Cashmere goat had a closer relationship while Leizhou black goat was the farthest. The location of goat breeds affected the gene flow.
Title : Eudragit And Chitosan – The Two Most Promising Polymer For Colon Drug Dilevery
Authors : Papola Vibhooti , Rajan G, Bisht Seema
Polymers occupy a major portion of materials used for controlled release formulations and drug-targeting systems because this class of materials presents seemingly endless diversity in topology and chemistry. This is a crucial advantage over other classes of materials to meet the ever-increasing requirements of new designs of drug delivery formulations. The colonic region of the GIT has become an increasingly important site for drug delivery and absorption.Colon specificity is more likely to be achieved with systems that utilize natural materials that are degraded by colonic bacterial enzyme. With the advances in polymer synthesis chemistry and technology, more defined, controlled, and biocompatible polymers are becoming available, and such polymers will contribute to new generations of biomimetic nanostructures and vehicles for carrying diagnostic and imaging agents, therapeutic drugs, prognostic reagents, and multiagents in the future.
Authors : Wesam Saber Morad, Yasser Rashed
Hepatitis A virus (HAV), a non enveloped RNA virus, is particularly resistant and contagious. The infection is spread chiefly by fecal- oral transmission and is a public health problem throughout the world. The main complication of HAV infection is fulminant hepatitis (FH). Methods: this study was done on 80 children, 50 with acute hepatitis A virus and 30 developed fulminant hepatic failure, 52 males and 28 females. In fulminant group 12 recovered with normal liver function, but 18 were died. Children recovered from fulminant liver failure had encephalopathy grade 1 or 2. Results: The study showed statistically significant differences between acute hepatitis A virus and low socioeconomic level and bad hygiene ( P < 0.004), children received anti convulsive therapy P < 0.009 and also with diabetic children P < 0.004. Total bilirubin > 9.56, Direct bilirubin > 5.11, ALT > 1365.7, AST > 1635.78, Prothrombin time prolonged more than 25.87 seconds are indices for increasing the risk for developing fulminant hepatic failure in children with acute HAV( P <0.000001, P <0.00001, P < 0.00001, P < 0.0001, P <0.00001 respectively). Mortallity rates was statistically significant related to prolonged prothrombin time, decreased ALT and AST, elevation of serum bilirubin and blood urea and serum creatinine and also with high grade of coma (grade 3 and 4).Conclusion: This study emphasize that early prediction of FHF can be predicted by simple tests and appropriate medical treatment could block further liver destruction and prevent development of FHF.
Title : Studies on pests and diseases of bumble bee (Bombus haemorrhoidalis SMITH) in India.
Authors : Avinash Chauhan, Sapna Katna , B.S. Rana ,H.K. Sharma
Bumble bees are wild pollinators and in many countries being reared commercially. In India, attempts are being made for the domestication of bumble bee, B. haemorrhoidalis. But targeted rearing success has not been accomplished till now. During the month of June-July, developing colonies start declining leading to the cent per cent loss of the bumble bee population. Keeping in view the immense importance of various pests and diseases of bumble bees in the successful rearing, studies during 2010-2012 were conducted to know the different pests and diseases for better domiciliation and commercialization of the bombiculture in our country. Fecundated queens of bumble bee, B. haemorrhoidalis were collected during spring season and were kept in wooden domiciles in the incubator at a temperature 26±1ºC and 65-70% relative humidity by feeding with fresh corbicular pollen and sucrose solution. Incidence of pests and diseases was observed with the development of colonies. Dead workers and queens were dissected and slides were prepared to study the causal organism of their death. The pests were found to be nematodes, conopid flies, mites and moths. Similarly, the colonies were also found to be affected with nosema and bacterial diseases. Percent infestation/infection of bumble bee colonies was calculated for each pest and disease. 8.83% colonies were found unaffected and survived till mid August. Bumble bee queens (17.65%) were infected by large number of juveniles and eggs of nematode, Sphareularia spp. (Sphaerulariidae). Conopid flies were present in the abdomen of 20.58% queens. Small oval reddish brown mites were located in 11.76% queens. While the brownish grey coloured moths were found to feed on the wax and pollen also caused losses to the 8.83% developing colonies of bumble bees. In 14.70% of queens, numerous nosema spores were found in the mid gut causing infection and finally leading their death. Rod like bacterial cells belonging to family Streptococcacae were found in gut of 17.65% colonies. Such incidences destroyed the colonies before the end of July every year.
Authors : Siddharth M. Patil , Anil B. Patil , Y.R.Hundekar
The present research work discussed the development of a UV spectrometric method for validation of Sumatriptan Succinate. It is simple, fast, accurate and cost efficient and reproducible spectrophotometric method, developed for the estimation of Sumatriptan Succinate as a pure API. The wavelength (max) was found to be 229 nm by using acetonitrile as a solvent for the Sumatriptan Succinate. The linearity for this drug at the selected wavelength lies between 2-20 μg/ml. Beer's law was obeyed in this concentration range with correlation coefficient of 0.999. The accuracy and precision of the method were determined and validated according to ICH guidelines. The method has good reproducibility with % RSD less than one. Thus proposed method can successfully applied for Sumatriptan Succinate in routine analysis work.
Title : A Rare Case Of Arteriovenous Malformation Of The Pinna And Review Of Literature
Authors :Dr.Bijendar Kumar Meena,Dr. Sweta Meena,Dr.Abhishek Gupta,Dr. M.L.Meena,Dr.S.C. Baser
The external ear is the second most common site for extracranial arteriovenous malformation in the head and neck. Arteriovenous malformations are rare in the head and neck region and generally arise from intracranial vessels. We present a case with spontaneous arteriovenous malformation related to the pinna arising from branches of external carotid artery and draining into external jugular vein. The role of colour Doppler sonography and computer tomography in the diagnosis and management of such cases is discussed along with a review of the literature.
Title : Microfilariae in Breast Fine Needle Aspiration- an Unusual Finding
Authors : Gunja Dwivedi , Namita Goyal, Shashi Sujanani, Chandra Mathur
Filariasis is a major public health problem particularly in tropical countries like India. The presence of microfilaria using fine needle aspiration cytology has been reported from various sites. However, the presence of filarial worm on breast aspirates has rarely been reported. Here, we report an unusual case in which aspiration cytology revealed presence of numerous microfilariae in breast lump.
Copyright JMSCR 2011
